Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice

Vascular dysregulation and cholinergic basal forebrain degeneration are both early pathological events in the development of Alzheimer’s disease (AD). Acetylcholine contributes to localised arterial dilatation and increased cerebral blood flow (CBF) during neurovascular coupling via activation of en...

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Bibliographic Details
Published in:Acta Neuropathol Commun
Main Authors: Nizari, Shereen, Wells, Jack A., Carare, Roxana O., Romero, Ignacio A., Hawkes, Cheryl A.
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791879/
https://ncbi.nlm.nih.gov/pubmed/33413694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01108-z
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