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Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice

Vascular dysregulation and cholinergic basal forebrain degeneration are both early pathological events in the development of Alzheimer’s disease (AD). Acetylcholine contributes to localised arterial dilatation and increased cerebral blood flow (CBF) during neurovascular coupling via activation of en...

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Dettagli Bibliografici
Pubblicato in:Acta Neuropathol Commun
Autori principali: Nizari, Shereen, Wells, Jack A., Carare, Roxana O., Romero, Ignacio A., Hawkes, Cheryl A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791879/
https://ncbi.nlm.nih.gov/pubmed/33413694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01108-z
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