Recombinant orthopoxvirus primes colon cancer for checkpoint inhibitor and cross-primes T cells for anti-tumor and anti-viral immunity

While it is known that oncolytic viruses can inflame and recruit immune cells to otherwise immunosuppressed tumor microenvironments, the influence of the anti-viral immune response on anti-tumor immunity is less clear across viral platforms and tumor types. CF33 is a recombinant orthopoxvirus backbo...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Kim, Sang-In, Park, Anthony K., Chaurasiya, Shyambabu, Kang, Seonah, Lu, Jianming, Yang, Annie, Sivanandam, Venkatesh, Zhang, Zhifang, Woo, Yanghee, Priceman, Saul J., Fong, Yuman, Warner, Susanne G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790874/
https://ncbi.nlm.nih.gov/pubmed/33262221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0405
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