A Novel Oncolytic Chimeric Orthopoxvirus Encoding Luciferase Enables Real-Time View of Colorectal Cancer Cell Infection

This study hypothesizes that a novel oncolytic chimeric orthopoxvirus CF33-Fluc is imageable and targets colorectal cancer cells (CRCs). A novel chimeric orthopoxvirus (CF33) was constructed. The thymidine kinase locus was replaced with firefly luciferase (Fluc) to yield a recombinant virus—CF33-Flu...

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Bibliographic Details
Published in:Mol Ther Oncolytics
Main Authors: O’Leary, Michael P., Warner, Susanne G., Kim, Sang-In, Chaurasiya, Shyambabu, Lu, Jianming, Choi, Audrey H., Park, Anthony K., Woo, Yanghee, Fong, Yuman, Chen, Nanhai G.
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026443/
https://ncbi.nlm.nih.gov/pubmed/29988502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2018.03.001
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