Novel oncolytic chimeric orthopoxvirus causes regression of pancreatic cancer xenografts and exhibits abscopal effect at a single low dose

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has been increasing by 0.5% per year in the United States. PDAC portends a dismal prognosis and novel therapies are needed. This study describes the generation and characterization of a novel oncolytic chimeric orthopoxvirus for the treatment of pa...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: O’Leary, Michael P., Choi, Audrey H., Kim, Sang-In, Chaurasiya, Shyambabu, Lu, Jianming, Park, Anthony K., Woo, Yanghee, Warner, Susanne G., Fong, Yuman, Chen, Nanhai G.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918769/
https://ncbi.nlm.nih.gov/pubmed/29699566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1483-x
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