A chimeric poxvirus with J2R (thymidine kinase) deletion shows safety and anti-tumor activity in lung cancer models

Oncolytic viruses have shown excellent safety profiles in preclinical and clinical studies; however, in most cases therapeutic benefits have been modest. We have previously reported the generation of a chimeric poxvirus (CF33), with significantly improved oncolytic characteristics, through chimeriza...

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Detalhes bibliográficos
Publicado no:Cancer Gene Ther
Main Authors: Chaurasiya, Shyambabu, Chen, Nanhai G., Lu, Jianming, Martin, Nikolas, Shen, Yinan, Kim, Sang-In, Warner, Susanne G., Woo, Yanghee, Fong, Yuman
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group US 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170804/
https://ncbi.nlm.nih.gov/pubmed/31209267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41417-019-0114-x
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