Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis

Endothelial–to–mesenchymal transition (EndMT) is a cellular transdifferentiation program in which endothelial cells partially lose their endothelial identity and acquire mesenchymal-like features. Renal capillary endothelial cells can undergo EndMT in association with persistent damage of the renal...

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Udgivet i:Sci Signal
Main Authors: Lovisa, Sara, Fletcher-Sananikone, Eliot, Sugimoto, Hikaru, Hensel, Janine, Lahiri, Sharmistha, Hertig, Alexandre, Taduri, Gangadhar, Lawson, Erica, Dewar, Rajan, Revuelta, Ignacio, Kato, Noritoshi, Wu, Chang-Jiun, Bassett, Roland L., Putluri, Nagireddy, Zeisberg, Michael, Zeisberg, Elisabeth M., LeBleu, Valerie S., Kalluri, Raghu
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790440/
https://ncbi.nlm.nih.gov/pubmed/32518142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaz2597
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