Activin–like kinase–3 activity is important for kidney regeneration and reversal of fibrosis

Molecules associated with TGF-β superfamily such as BMPs and TGF-β are key regulators of inflammation, apoptosis and cellular transitions. Here, we demonstrate that the BMP receptor activin–like kinase 3 (Alk3) is elevated early in response to kidney injury and its deletion in the tubular epithelium...

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Библиографические подробности
Главные авторы: Sugimoto, Hikaru, LeBleu, Valerie S., Basukonda, Dattatreyamurty, Keck, Peter, Taduri, Gangadhar, Bechtel, Wibke, Okada, Hirokazu, Carlson, William, Bey, Philippe, Rusckowski, Mary, Tampe, Björn, Tampe, Desiree, Kanasaki, Keizo, Zeisberg, Michael, Kalluri, Raghu
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3998727/
https://ncbi.nlm.nih.gov/pubmed/22306733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2629
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