Podoplanin(+) tumor lymphatics are rate limiting for breast cancer metastasis

Metastatic dissemination employs both the blood and lymphatic vascular systems. Solid tumors dynamically remodel and generate both vessel types during cancer progression. Lymphatic vessel invasion and cancer cells in the tumor-draining lymph nodes (LNs) are prognostic markers for breast cancer metas...

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Udgivet i:PLoS Biol
Main Authors: Chen, Yang, Keskin, Doruk, Sugimoto, Hikaru, Kanasaki, Keizo, Phillips, Patricia E., Bizarro, Lauren, Sharpe, Arlene, LeBleu, Valerie S., Kalluri, Raghu
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310240/
https://ncbi.nlm.nih.gov/pubmed/30592710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005907
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