Thrombospondin-1 Deficiency Causes a Shift from Fibroproliferative to Inflammatory Kidney Disease and Delays Onset of Renal Failure

Thrombospondin-1 (TSP1) is a multifunctional matricellular protein known to promote progression of chronic kidney disease. To gain insight into the underlying mechanisms through which TSP1 accelerates chronic kidney disease, we compared disease progression in Col4a3 knockout (KO) mice, which develop...

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Опубликовано в: :Am J Pathol
Главные авторы: Zeisberg, Michael, Tampe, Björn, LeBleu, Valerie, Tampe, Desiree, Zeisberg, Elisabeth M., Kalluri, Raghu
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2014
Предметы:
Regular Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715225/
https://ncbi.nlm.nih.gov/pubmed/25111226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.06.014
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