Thrombospondin-1 Deficiency Causes a Shift from Fibroproliferative to Inflammatory Kidney Disease and Delays Onset of Renal Failure

Thrombospondin-1 (TSP1) is a multifunctional matricellular protein known to promote progression of chronic kidney disease. To gain insight into the underlying mechanisms through which TSP1 accelerates chronic kidney disease, we compared disease progression in Col4a3 knockout (KO) mice, which develop...

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Bibliographic Details
Published in:Am J Pathol
Main Authors: Zeisberg, Michael, Tampe, Björn, LeBleu, Valerie, Tampe, Desiree, Zeisberg, Elisabeth M., Kalluri, Raghu
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2014
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715225/
https://ncbi.nlm.nih.gov/pubmed/25111226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.06.014
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