Thrombospondin-1 Deficiency Causes a Shift from Fibroproliferative to Inflammatory Kidney Disease and Delays Onset of Renal Failure

Thrombospondin-1 (TSP1) is a multifunctional matricellular protein known to promote progression of chronic kidney disease. To gain insight into the underlying mechanisms through which TSP1 accelerates chronic kidney disease, we compared disease progression in Col4a3 knockout (KO) mice, which develop...

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Publicat a:Am J Pathol
Autors principals: Zeisberg, Michael, Tampe, Björn, LeBleu, Valerie, Tampe, Desiree, Zeisberg, Elisabeth M., Kalluri, Raghu
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2014
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715225/
https://ncbi.nlm.nih.gov/pubmed/25111226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.06.014
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