Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease

Progression of chronic kidney disease remains a principal problem in clinical nephrology and there is a pressing need for novel therapeutics and biomarkers. Aberrant promoter CpG island methylation and subsequent transcriptional silencing of specific genes have emerged as contributors to progression...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Tampe, Björn, Tampe, Desiree, Zeisberg, Elisabeth M., Müller, Gerhard A., Bechtel-Walz, Wibke, Koziolek, Michael, Kalluri, Raghu, Zeisberg, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337426/
https://ncbi.nlm.nih.gov/pubmed/25717475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2014.11.005
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