Novel, non-nitrocatechol catechol-O-methyltransferase inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility

RATIONALE: Cognitive impairment is a primary feature of many neuropsychiatric disorders and there is a need for new therapeutic options. Catechol-O-methyltransferase (COMT) inhibitors modulate cortical dopaminergic function and have been proposed as potential cognitive enhancers. Unfortunately, curr...

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Publicado en:Psychopharmacology (Berl)
Main Authors: Byers, Spencer, Buchler, Ingrid P., DePasquale, Michael, Rowley, Helen L., Kulkarni, Rajiv S., Pinder, Lucy, Kolobova, Anna, Li, Cailian, Au, Vinh, Akuma, Daniel, Zhang, Gongliang, Wei, Huijun, Cheetham, Sharon C., Barrow, James C., Carr, Gregory V.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790123/
https://ncbi.nlm.nih.gov/pubmed/32474681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-020-05566-0
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