Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain

Impaired dopamine activity in the dorsolateral prefrontal cortex (DLPFC) is thought to contribute to cognitive deficits in diseases such as schizophrenia, attention deficit hyperactivity disorder (ADHD) and traumatic brain injury. Catechol-O-methyltransfease (COMT) metabolizes dopamine and is an imp...

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Bibliographic Details
Published in:Eur J Pharmacol
Main Authors: Su, Yupin, DePasquale, Michael, Liao, Gangling, Buchler, Ingrid, Zhang, Gongliang, Byers, Spencer, Carr, Gregory V., Barrow, James, Wei, Huijun
Format: Artigo
Language:Inglês
Published: 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7962326/
https://ncbi.nlm.nih.gov/pubmed/33503461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2021.173909
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