Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase

A series of 8-hydroxy quinolines were identified as potent inhibitors of catechol O-methyltransferase (COMT) with selectivity for the membrane-bound form of the enzyme. Small substituents at the 7-position of the quinoline were found to increase metabolic stability without sacrificing potency. Compo...

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Опубликовано в: :J Med Chem
Главные авторы: Buchler, Ingrid, Akuma, Daniel, Au, Vinh, Carr, Gregory, de León, Pablo, DePasquale, Michael, Ernst, Glen, Huang, Yifang, Kimos, Martha, Kolobova, Anna, Poslusney, Michael, Wei, Huijun, Swinnen, Dominique, Montel, Florian, Moureau, Florence, Jigorel, Emilie, Schulze, Monika-Sarah E.D., Wood, Martyn, Barrow, James C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398604/
https://ncbi.nlm.nih.gov/pubmed/30272964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01126
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