Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT)

[Image: see text] 3-Hydroxy-4-pyridinones and 5-hydroxy-4-pyrimidinones were identified as inhibitors of catechol-O-methyltransferase (COMT) in a high-throughput screen. These heterocyclic catechol mimics exhibit potent inhibition of the enzyme and an improved toxicity profile versus the marketed ni...

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Bibliografski detalji
Izdano u:ACS Med Chem Lett
Glavni autori: Harrison, Scott T., Poslusney, Michael S., Mulhearn, James J., Zhao, Zhijian, Kett, Nathan R., Schubert, Jeffrey W., Melamed, Jeffrey Y., Allison, Timothy J., Patel, Sangita B., Sanders, John M., Sharma, Sujata, Smith, Robert F., Hall, Dawn L., Robinson, Ronald G., Sachs, Nancy A., Hutson, Pete H., Wolkenberg, Scott E., Barrow, James C.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2015
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360154/
https://ncbi.nlm.nih.gov/pubmed/25815153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500502d
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