Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT)

[Image: see text] 3-Hydroxy-4-pyridinones and 5-hydroxy-4-pyrimidinones were identified as inhibitors of catechol-O-methyltransferase (COMT) in a high-throughput screen. These heterocyclic catechol mimics exhibit potent inhibition of the enzyme and an improved toxicity profile versus the marketed ni...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Harrison, Scott T., Poslusney, Michael S., Mulhearn, James J., Zhao, Zhijian, Kett, Nathan R., Schubert, Jeffrey W., Melamed, Jeffrey Y., Allison, Timothy J., Patel, Sangita B., Sanders, John M., Sharma, Sujata, Smith, Robert F., Hall, Dawn L., Robinson, Ronald G., Sachs, Nancy A., Hutson, Pete H., Wolkenberg, Scott E., Barrow, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360154/
https://ncbi.nlm.nih.gov/pubmed/25815153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500502d
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