Characterization of Non-Nitrocatechol Pan and Isoform Specific Catechol-O-methyltransferase Inhibitors and Substrates

[Image: see text] Reduced dopamine neurotransmission in the prefrontal cortex has been implicated as causal for the negative symptoms and cognitive deficit associated with schizophrenia; thus, a compound which selectively enhances dopamine neurotransmission in the prefrontal cortex may have therapeu...

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Main Authors: Robinson, Ronald G., Smith, Sean M., Wolkenberg, Scott E., Kandebo, Monika, Yao, Lihang, Gibson, Christopher R., Harrison, Scott T., Polsky-Fisher, Stacey, Barrow, James C., Manley, Peter J., Mulhearn, James J., Nanda, Kausik K., Schubert, Jeffrey W., Trotter, B. Wesley, Zhao, Zhijian, Sanders, John M., Smith, Robert F., McLoughlin, Debra, Sharma, Sujata, Hall, Dawn L., Walker, Tiffany L., Kershner, Jennifer L., Bhandari, Neetesh, Hutson, Pete H., Sachs, Nancy A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369789/
https://ncbi.nlm.nih.gov/pubmed/22860182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200109w
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