Pharmacological profile of opicapone, a thirdgeneration nitrocatechol catechol-O-methyl transferase inhibitor, in the rat

BACKGROUND AND PURPOSE: Catechol-O-methyltransferase (COMT) is an important target in the levodopa treatment of Parkinson's disease; however, the inhibitors available have problems, and not all patients benefit from their efficacy. Opicapone was developed to overcome those limitations. In this...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Bonifácio, M J, Torrão, L, Loureiro, A I, Palma, P N, Wright, L C, Soares-da-Silva, P
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376453/
https://ncbi.nlm.nih.gov/pubmed/25409768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13020
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