Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple dose administration in healthy subjects

AIMS: The aim of this study was to assess the tolerability, pharmacokinetics and inhibitory effect on erythrocyte soluble catechol-O-methyltransferase (S-COMT) activity following repeated doses of opicapone. METHODS: This randomized, placebo-controlled, double-blind study enrolled healthy male subje...

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Detalhes bibliográficos
Main Authors: Rocha, José Francisco, Almeida, Luis, Falcão, Amílcar, Palma, P Nuno, Loureiro, Ana I, Pinto, Roberto, Bonifácio, Maria João, Wright, Lyndon C, Nunes, Teresa, Soares-da-Silva, Patrício
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Pharmacokinetic Dynamic Relationships
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853535/
https://ncbi.nlm.nih.gov/pubmed/23336248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12081
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