Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT)

[Image: see text] 3-Hydroxy-4-pyridinones and 5-hydroxy-4-pyrimidinones were identified as inhibitors of catechol-O-methyltransferase (COMT) in a high-throughput screen. These heterocyclic catechol mimics exhibit potent inhibition of the enzyme and an improved toxicity profile versus the marketed ni...

Full description

Saved in:
Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Harrison, Scott T., Poslusney, Michael S., Mulhearn, James J., Zhao, Zhijian, Kett, Nathan R., Schubert, Jeffrey W., Melamed, Jeffrey Y., Allison, Timothy J., Patel, Sangita B., Sanders, John M., Sharma, Sujata, Smith, Robert F., Hall, Dawn L., Robinson, Ronald G., Sachs, Nancy A., Hutson, Pete H., Wolkenberg, Scott E., Barrow, James C.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2015
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360154/
https://ncbi.nlm.nih.gov/pubmed/25815153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500502d
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items