Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT)

[Image: see text] 3-Hydroxy-4-pyridinones and 5-hydroxy-4-pyrimidinones were identified as inhibitors of catechol-O-methyltransferase (COMT) in a high-throughput screen. These heterocyclic catechol mimics exhibit potent inhibition of the enzyme and an improved toxicity profile versus the marketed ni...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Harrison, Scott T., Poslusney, Michael S., Mulhearn, James J., Zhao, Zhijian, Kett, Nathan R., Schubert, Jeffrey W., Melamed, Jeffrey Y., Allison, Timothy J., Patel, Sangita B., Sanders, John M., Sharma, Sujata, Smith, Robert F., Hall, Dawn L., Robinson, Ronald G., Sachs, Nancy A., Hutson, Pete H., Wolkenberg, Scott E., Barrow, James C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2015
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360154/
https://ncbi.nlm.nih.gov/pubmed/25815153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500502d
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