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Factor VIII binding affects the mechanical unraveling of the A2 domain of von Willebrand factor
BACKGROUND. Proteolytic cleavage of von Willebrand factor (VWF) by ADAMTS13 is crucial for normal hemostasis. Our previous studies demonstrate that binding of coagulation factor VIII (or FVIII) to VWF enhances the proteolytic cleavage of VWF by ADAMTS13 under shear. OBJECTIVES. Present study aims to...
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| Publicado no: | J Thromb Haemost |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7789802/ https://ncbi.nlm.nih.gov/pubmed/32544272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14962 |
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