Human and mouse PD-L1: similar molecular structure, but different druggability profiles

In the development of PD-L1-blocking therapeutics, it is essential to transfer initial in vitro findings into proper in vivo animal models. Classical immunocompetent mice are attractive due to high accessibility and low experimental costs. However, it is unknown whether inter-species differences in...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Magiera-Mularz, Katarzyna, Kocik, Justyna, Musielak, Bogdan, Plewka, Jacek, Sala, Dominik, Machula, Monika, Grudnik, Przemyslaw, Hajduk, Malgorzata, Czepiel, Marcin, Siedlar, Maciej, Holak, Tad A., Skalniak, Lukasz
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7788105/
https://ncbi.nlm.nih.gov/pubmed/33437940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101960
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