Di-bromo-Based Small-Molecule Inhibitors of the PD-1/PD-L1 Immune Checkpoint

[Image: see text] Immune checkpoint blockade is one of the most promising strategies of cancer immunotherapy. However, unlike classical targeted therapies, it is currently solely based on expensive monoclonal antibodies, which often inflict immune-related adverse events. Herein, we propose a novel s...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Konieczny, Magdalena, Musielak, Bogdan, Kocik, Justyna, Skalniak, Lukasz, Sala, Dominik, Czub, Miroslawa, Magiera-Mularz, Katarzyna, Rodriguez, Ismael, Myrcha, Maja, Stec, Malgorzata, Siedlar, Maciej, Holak, Tad A., Plewka, Jacek
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2020
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584369/
https://ncbi.nlm.nih.gov/pubmed/32936638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01260
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