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Bioactive macrocyclic inhibitors of the PD-1/PD-L1 immune checkpoint
Blockade of the immunoinhibitory PD-1/PD-L1 pathway using monoclonal antibodies has shown impressive results with durable clinical antitumor responses. Anti-PD-1 and anti-PD-L1 antibodies have now been approved for the treatment of a number of tumor types whereas the development of small molecules t...
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| Pubblicato in: | Angew Chem Int Ed Engl |
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| Autori principali: | , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6400216/ https://ncbi.nlm.nih.gov/pubmed/28881104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201707707 |
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