Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells

Antibodies targeting the PD-1/PD-L1 immune checkpoint achieved spectacular success in anticancer therapy in the recent years. In contrast, no small molecules with cellular activity have been reported so far. Here we provide evidence that small molecules are capable of alleviating the PD-1/PD-L1 immu...

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Vydáno v:Oncotarget
Hlavní autoři: Skalniak, Lukasz, Zak, Krzysztof M., Guzik, Katarzyna, Magiera, Katarzyna, Musielak, Bogdan, Pachota, Magdalena, Szelazek, Bozena, Kocik, Justyna, Grudnik, Przemyslaw, Tomala, Marcin, Krzanik, Sylwia, Pyrc, Krzysztof, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641120/
https://ncbi.nlm.nih.gov/pubmed/29069777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20050
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