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Immune Checkpoint PD-1/PD-L1: Is There Life Beyond Antibodies?

[Image: see text] The PD-1/PD-L1 interaction has emerged as a significant target in cancer immunotherapy. Current medications include monoclonal antibodies, which have shown impressive clinical results in the treatment of several types of tumors. The cocrystal structure of human PD-1 and PD-L1 is ex...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Konstantinidou, Markella, Zarganes-Tzitzikas, Tryfon, Magiera-Mularz, Katarzyna, Holak, Tad A., Dömling, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280658/
https://ncbi.nlm.nih.gov/pubmed/29178534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201710407
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