Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells

Antibodies targeting the PD-1/PD-L1 immune checkpoint achieved spectacular success in anticancer therapy in the recent years. In contrast, no small molecules with cellular activity have been reported so far. Here we provide evidence that small molecules are capable of alleviating the PD-1/PD-L1 immu...

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發表在:Oncotarget
Main Authors: Skalniak, Lukasz, Zak, Krzysztof M., Guzik, Katarzyna, Magiera, Katarzyna, Musielak, Bogdan, Pachota, Magdalena, Szelazek, Bozena, Kocik, Justyna, Grudnik, Przemyslaw, Tomala, Marcin, Krzanik, Sylwia, Pyrc, Krzysztof, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2017
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641120/
https://ncbi.nlm.nih.gov/pubmed/29069777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20050
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