Preoperative Carfilzomib and Lulizumab based desensitization prolongs graft survival in a sensitized NHP model.

Sensitized patients are difficult to transplant due to pre-formed anti-donor immunity. We have previously reported successful desensitization using carfilzomib and belatacept in a non-human primate (NHP) model. Here we evaluated selective blockade of the co-stimulatory signal (CD28-B7) with Lulizuma...

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Pubblicato in:Kidney Int
Autori principali: Schroder, Paul M., Schmitz, Robin, Fitch, Zachary W., Ezekian, Brian, Yoon, Janghoon, Choi, Ashley Y., Manook, Miriam, Barbas, Andrew, Leopardi, Frank, Song, Mingqing, Farris, Alton B., Collins, Bradley, Kwun, Jean, Knechtle, Stuart J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785689/
https://ncbi.nlm.nih.gov/pubmed/32898569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2020.08.020
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