Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients

BACKGROUND: Patients with broad HLA sensitization have poor access to donor organs, high mortality while waiting for kidney transplant, and inferior graft survival. Although desensitization strategies permit transplantation via lowering of donor-specific antibodies, the B cell–response axis from ger...

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Библиографические подробности
Опубликовано в: :J Am Soc Nephrol
Главные авторы: Ezekian, Brian, Schroder, Paul M., Mulvihill, Michael S., Barbas, Andrew, Collins, Bradley, Freischlag, Kyle, Yoon, Janghoon, Yi, John S., Smith, Felicitas, Olaso, Danae, Saccoccio, Frances M., Permar, Sallie, Farris, Alton B., Kwun, Jean, Knechtle, Stuart J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Nephrology 2019
Предметы:
Basic Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900797/
https://ncbi.nlm.nih.gov/pubmed/31658991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019030304
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