Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates

The detrimental effects of donor-directed antibodies in sensitized transplant patients remain a difficult immunologic barrier to successful organ transplantation. Antibody removal is often followed by rebound. Proteasome inhibitors (PIs) deplete antibody-producing plasma cells (PCs) but have shown m...

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Kwun, Jean, Burghuber, Christopher, Manook, Miriam, Ezekian, Brian, Park, Jaeberm, Yoon, Janghoon, Yi, John S., Iwakoshi, Neal, Gibby, Adriana, Hong, Jung Joo, Farris, Alton B., Kirk, Allan D., Knechtle, Stuart J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Transplantation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737135/
https://ncbi.nlm.nih.gov/pubmed/29296858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017010991
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