IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade

Despite its excellent efficacy in controlling T cell mediated acute rejection, lymphocyte depletion may promote a humoral response. While T cell repopulation after depletion has been evaluated in many aspects, the B cell response has not been fully elucidated. We tested the hypothesis that the mecha...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Kwun, Jean, Park, Jaeberm, Yi, John S., Farris, Alton B., Kirk, Allan D., Knechtle, Stuart J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196291/
https://ncbi.nlm.nih.gov/pubmed/30374350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02323
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