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Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection
De novo donor-specific antibody (DSA) after organ transplantation promotes antibody-mediated rejection (AMR) and causes late graft loss. Previously, we demonstrated that depletion using anti-CD3 immunotoxin (IT) combined with tacrolimus and alefacept (AMR regimen) reliably induced early DSA producti...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3985346/ https://ncbi.nlm.nih.gov/pubmed/24354871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.12526 |
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