Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients

BACKGROUND: Patients with broad HLA sensitization have poor access to donor organs, high mortality while waiting for kidney transplant, and inferior graft survival. Although desensitization strategies permit transplantation via lowering of donor-specific antibodies, the B cell–response axis from ger...

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Detaylı Bibliyografya
Yayımlandı:J Am Soc Nephrol
Asıl Yazarlar: Ezekian, Brian, Schroder, Paul M., Mulvihill, Michael S., Barbas, Andrew, Collins, Bradley, Freischlag, Kyle, Yoon, Janghoon, Yi, John S., Smith, Felicitas, Olaso, Danae, Saccoccio, Frances M., Permar, Sallie, Farris, Alton B., Kwun, Jean, Knechtle, Stuart J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Nephrology 2019
Konular:
Basic Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900797/
https://ncbi.nlm.nih.gov/pubmed/31658991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019030304
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