Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model

BACKGROUND: In transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor-specific antibody (DSA), yet both have limitations. We sought to test the efficacy of targeting the IgG recycling mechanism of the neonatal Fc receptor (FcRn)...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Manook, Miriam, Flores, Walter J., Schmitz, Robin, Fitch, Zachary, Yoon, Janghoon, Bae, Yeeun, Shaw, Brian, Kirk, Allan, Harnois, Melissa, Permar, Sallie, Farris, Alton B., Magnani, Diogo M., Kwun, Jean, Knechtle, Stuart
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8207189/
https://ncbi.nlm.nih.gov/pubmed/34149698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.660900
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