ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

Inflammation and cell death are closely linked arms of the host immune response to infection, which when carefully balanced ensure host survival. One example of this balance is the tightly regulated transition from TNFR1-associated pro-inflammatory complex I to pro-death complex II. By contrast, her...

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Pubblicato in:Nat Commun
Autori principali: Muendlein, Hayley I., Connolly, Wilson M., Magri, Zoie, Smirnova, Irina, Ilyukha, Vladimir, Gautam, Avishekh, Degterev, Alexei, Poltorak, Alexander
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7782486/
https://ncbi.nlm.nih.gov/pubmed/33397971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20357-z
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