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ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

Inflammation and cell death are closely linked arms of the host immune response to infection, which when carefully balanced ensure host survival. One example of this balance is the tightly regulated transition from TNFR1-associated pro-inflammatory complex I to pro-death complex II. By contrast, her...

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Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Muendlein, Hayley I., Connolly, Wilson M., Magri, Zoie, Smirnova, Irina, Ilyukha, Vladimir, Gautam, Avishekh, Degterev, Alexei, Poltorak, Alexander
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7782486/
https://ncbi.nlm.nih.gov/pubmed/33397971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20357-z
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