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Immunoprecipitation strategies to isolate RIPK1/RIPK3 complexes in mouse macrophages

A large protein complex, containing RIPK1, RIPK3 and caspase-8 and known as Complex II, has emerged as one of the key mediators of cell death downstream from a range of innate immune triggers. This regulatory mechanism plays a prominent role in macrophages where Complex II has been linked to apoptos...

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Bibliografiske detaljer
Udgivet i:Curr Protoc
Main Authors: Siokas, Ioannis, Zhang, Dingqiang, Poltorak, Alexander, Muendlein, Hayley, Degterev, Alexei
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208500/
https://ncbi.nlm.nih.gov/pubmed/34106523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpz1.156
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