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cFLIP(L) protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation

Cell death and inflammation are interdependent host responses to infection. During pyroptotic cell death, interleukin-1β (IL-1β) release occurs through caspase-1 and caspase-11–mediated gasdermin D pore formation. In vivo, responses to lipopolysaccharide (LPS) result in IL-1β secretion. In vitro, ho...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Muendlein, Hayley I., Jetton, David, Connolly, Wilson M., Eidell, Keith P., Magri, Zoie, Smirnova, Irina, Poltorak, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375259/
https://ncbi.nlm.nih.gov/pubmed/32193329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay3878
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