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Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo
cFLIP, an inhibitor of apoptosis, is a crucial regulator of cellular death by apoptosis and necroptosis; its importance in development is exemplified by the embryonic lethality in cFLIP–deficient animals. A homolog of caspase 8 (CASP8), cFLIP exists in two main isoforms: cFLIP(L) (long) and cFLIP(R)...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4760830/ https://ncbi.nlm.nih.gov/pubmed/26798068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1517562113 |
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