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cFLIP(L) protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation
Cell death and inflammation are interdependent host responses to infection. During pyroptotic cell death, interleukin-1β (IL-1β) release occurs through caspase-1 and caspase-11–mediated gasdermin D pore formation. In vivo, responses to lipopolysaccharide (LPS) result in IL-1β secretion. In vitro, ho...
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| Vydáno v: | Science |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7375259/ https://ncbi.nlm.nih.gov/pubmed/32193329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay3878 |
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