A novel gene-diet interaction promotes organismal lifespan and host protection during infection via the mitochondrial UPR

Cells use a variety of mechanisms to maintain optimal mitochondrial function including the mitochondrial unfolded protein response (UPR(mt)). The UPR(mt) mitigates mitochondrial dysfunction by differentially regulating mitoprotective gene expression through the transcription factor ATFS-1. Since UPR...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Amin, Mustafi Raisa, Mahmud, Siraje Arif, Dowgielewicz, Jonathan L., Sapkota, Madhab, Pellegrino, Mark W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781476/
https://ncbi.nlm.nih.gov/pubmed/33338044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009234
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