A novel gene-diet interaction promotes organismal lifespan and host protection during infection via the mitochondrial UPR

Cells use a variety of mechanisms to maintain optimal mitochondrial function including the mitochondrial unfolded protein response (UPR(mt)). The UPR(mt) mitigates mitochondrial dysfunction by differentially regulating mitoprotective gene expression through the transcription factor ATFS-1. Since UPR...

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Detalles Bibliográficos
Publicado en:PLoS Genet
Main Authors: Amin, Mustafi Raisa, Mahmud, Siraje Arif, Dowgielewicz, Jonathan L., Sapkota, Madhab, Pellegrino, Mark W.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781476/
https://ncbi.nlm.nih.gov/pubmed/33338044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009234
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