A novel gene-diet interaction promotes organismal lifespan and host protection during infection via the mitochondrial UPR

Cells use a variety of mechanisms to maintain optimal mitochondrial function including the mitochondrial unfolded protein response (UPR(mt)). The UPR(mt) mitigates mitochondrial dysfunction by differentially regulating mitoprotective gene expression through the transcription factor ATFS-1. Since UPR...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Amin, Mustafi Raisa, Mahmud, Siraje Arif, Dowgielewicz, Jonathan L., Sapkota, Madhab, Pellegrino, Mark W.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781476/
https://ncbi.nlm.nih.gov/pubmed/33338044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009234
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