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Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial UPR
Mitochondrial genomes (mtDNA) encode essential oxidative phosphorylation (OxPhos) components. Because hundreds of mtDNAs exist per cell, the presence of a deletion in a single mtDNA has little impact. However, if the deletion genome is enriched, OxPhos declines resulting in cellular dysfunction. For...
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| Publicado no: | Nature |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4873342/ https://ncbi.nlm.nih.gov/pubmed/27135930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17989 |
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