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ZEB1 and oncogenic Ras constitute a regulatory switch for stimulus‐dependent E‐cadherin downregulation

E‐cadherin, an epithelial cell–specific cell adhesion molecule, has both promoting and suppressing effects on tumor invasion and metastasis. It is often downregulated during cancer progression through gene deletion/mutation, transcriptional repression, or epigenetic silencing. We describe a novel re...

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Bibliografiske detaljer
Udgivet i:Cancer Sci
Main Authors: Otake, Shigeo, Itoh, Yuka, Omata, Chiho, Saitoh, Masao, Miyazawa, Keiji
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780036/
https://ncbi.nlm.nih.gov/pubmed/33068045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14701
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