A comparative analysis of Smad-responsive motifs identifies multiple regulatory inputs for TGF-β transcriptional activation

Smad proteins are transcriptional regulators activated by TGF-β. They are known to bind to two distinct Smad-responsive motifs, namely the Smad-binding element (SBE) (5′-GTCTAGAC-3′) and CAGA motifs (5′-AGCCAGACA-3′ or 5′-TGTCTGGCT-3′). However, the mechanisms by which these motifs promote Smad acti...

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Vydáno v:J Biol Chem
Hlavní autoři: Itoh, Yuka, Koinuma, Daizo, Omata, Chiho, Ogami, Tomohiro, Motizuki, Mitsuyoshi, Yaguchi, So-ichi, Itoh, Takuma, Miyake, Kunio, Tsutsumi, Shuichi, Aburatani, Hiroyuki, Saitoh, Masao, Miyazono, Kohei, Miyazawa, Keiji
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802517/
https://ncbi.nlm.nih.gov/pubmed/31481467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009877
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