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ZEB1 and oncogenic Ras constitute a regulatory switch for stimulus‐dependent E‐cadherin downregulation

E‐cadherin, an epithelial cell–specific cell adhesion molecule, has both promoting and suppressing effects on tumor invasion and metastasis. It is often downregulated during cancer progression through gene deletion/mutation, transcriptional repression, or epigenetic silencing. We describe a novel re...

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Библиографические подробности
Опубликовано в: :Cancer Sci
Главные авторы: Otake, Shigeo, Itoh, Yuka, Omata, Chiho, Saitoh, Masao, Miyazawa, Keiji
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780036/
https://ncbi.nlm.nih.gov/pubmed/33068045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14701
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