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ZEB1 and oncogenic Ras constitute a regulatory switch for stimulus‐dependent E‐cadherin downregulation

E‐cadherin, an epithelial cell–specific cell adhesion molecule, has both promoting and suppressing effects on tumor invasion and metastasis. It is often downregulated during cancer progression through gene deletion/mutation, transcriptional repression, or epigenetic silencing. We describe a novel re...

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Detalles Bibliográficos
Publicado en:Cancer Sci
Main Authors: Otake, Shigeo, Itoh, Yuka, Omata, Chiho, Saitoh, Masao, Miyazawa, Keiji
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780036/
https://ncbi.nlm.nih.gov/pubmed/33068045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14701
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