Quantitative Whole-Body Imaging of I-124-Labeled Adeno-Associated Viral Vector Biodistribution in Nonhuman Primates

A method is presented for quantitative analysis of the biodistribution of adeno-associated virus (AAV) gene transfer vectors following in vivo administration. We used iodine-124 (I-124) radiolabeling of the AAV capsid and positron emission tomography combined with compartmental modeling to quantify...

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Bibliografiske detaljer
Udgivet i:Hum Gene Ther
Main Authors: Ballon, Douglas J., Rosenberg, Jonathan B., Fung, Edward K., Nikolopoulou, Anastasia, Kothari, Paresh, De, Bishnu P., He, Bin, Chen, Alvin, Heier, Linda A., Sondhi, Dolan, Kaminsky, Stephen M., Mozley, Paul David, Babich, John W., Crystal, Ronald G.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc., publishers 2020
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769048/
https://ncbi.nlm.nih.gov/pubmed/33233962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2020.116
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