Biodistribution of Adeno-associated Virus Type-2 in Nonhuman Primates after Convection-enhanced Delivery to Brain

A combination treatment of AAV2-hAADC with oral levodopa is a novel therapeutic approach that is being developed for late-stage Parkinson's disease. Biodistribution of AAV2-hAADC was assessed over a wide range of vector dose in 12 monkeys with parkinsonian syndrome, 6 months after intraputamena...

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Main Authors: Cunningham, Janet, Pivirotto, Philip, Bringas, John, Suzuki, Brian, Vijay, Sharmila, Sanftner, Laura, Kitamura, Marina, Chan, Curtis, Bankiewicz, Krystof S
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766605/
https://ncbi.nlm.nih.gov/pubmed/18523450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.111
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