Novel Platform for MRI-Guided Convection-Enhanced Delivery of Therapeutics: Preclinical Validation in Nonhuman Primate Brain

BACKGROUND/AIMS: A skull-mounted aiming device and integrated software platform has been developed for MRI-guided neurological interventions. In anticipation of upcoming gene therapy clinical trials, we adapted this device for real-time convection-enhanced delivery of therapeutics via a custom-desig...

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Detalhes bibliográficos
Main Authors: Richardson, R. Mark, Kells, Adrian P., Martin, Alastair J., Larson, Paul S., Starr, Philip A., Piferi, Peter G., Bates, Geoffrey, Tansey, Lisa, Rosenbluth, Kathryn H., Bringas, John R., Berger, Mitchel S., Bankiewicz, Krystof S.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2011
Assuntos:
Laboratory Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085040/
https://ncbi.nlm.nih.gov/pubmed/21494065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000323544
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